Stem cell-based therapy for malignant glioma
نویسندگان
چکیده
منابع مشابه
Title: Stem Cell-Based Therapy for Malignant Glioma Running title: Stem Cells for Malignant Glioma
Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammati...
متن کاملStem cell therapies for malignant glioma.
The prognosis for patients with malignant glioma, which is the most common primary intracranial neoplasm, remains dismal despite significant progress in neurooncological therapies and technology. This is largely due to the inability of current treatment strategies to address the highly invasive nature of this disease. Malignant glial cells often disseminate throughout the brain, making it excee...
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BACKGROUND Natural killer (NK) cells are highly efficient in the cellular immune response against malignant tumors without restriction of major histocompatibility complex. However clinical studies using autologous NK cells have been reported in only a very limited number of cases, due to the fact that selective NK expansion is difficult to achieve in this patient population. Here, we report the...
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Accepted, February 12, 2003. MALIGNANT GLIOMAS ARE among the most challenging of all cancers to treat successfully, being characterized not only by aggressive proliferation and expansion but also by inexorable tumor invasion into distant brain tissue. Although considerable progress has been made in the treatment of these tumors with combinations of surgery, radiotherapy, and chemotherapy, these...
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Conventional therapies have made little impact on the poor prognosis associated with malignant glioma. Recent advances in the construction of replication-defective Herpes Simplex Virus (HPV)-based vectors have offered an opportunity to explore the therapeutic affects of simultaneous multiple transgene delivery to these tumours. Identification of co-operative molecular targets has enabled the ra...
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ژورنال
عنوان ژورنال: Cancer Treatment Reviews
سال: 2013
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2012.06.006